Evidence map›Paper›PMID 42800460›Full record

ArticleRedox biology2026

CLPP loss confers sex-specific protection from renal ischemia reperfusion injury.

Lea Isermann, Pedro Rojas-Morales, Katharina Senft, Nidhi Nair, Linda Baumann, Marijana Croon, Viktoria Katharina Lauterbach, Heike Göbel, Francesco Landini, Chiara Tuma and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lea IsermannFaculty of Medicine, University Hospital Cologne, Institute for Mitochondrial Diseases in Ageing, University of Cologne, Cologne, 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Pedro Rojas-MoralesCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Katharina SenftFaculty of Medicine, University Hospital Cologne, Institute for Mitochondrial Diseases in Ageing, University of Cologne, Cologne, 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Nidhi NairFaculty of Medicine, University Hospital Cologne, Institute for Mitochondrial Diseases in Ageing, University of Cologne, Cologne, 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Linda BaumannFaculty of Medicine, University Hospital Cologne, Institute for Mitochondrial Diseases in Ageing, University of Cologne, Cologne, 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Marijana CroonFaculty of Medicine, University Hospital Cologne, Institute for Mitochondrial Diseases in Ageing, University of Cologne, Cologne, 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Viktoria Katharina LauterbachRedox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, Germany.
Heike GöbelDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Francesco LandiniDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Chiara TumaInstitute of Biochemistry, Center of Preventive Doping Research, German Sport University Cologne, Cologne, 50933, Germany; German Research Centre of Elite Sports (Momentum), German Sport University Cologne, Cologne, 50933, Germany.
Ignacio Sottorff-NeculhuequeCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany.
Mario ThevisInstitute of Biochemistry, Center of Preventive Doping Research, German Sport University Cologne, Cologne, 50933, Germany; European Monitoring Center for Emerging Doping Agents (EuMoCEDA), Cologne, 50933, Germany.
Michael IgnarskiCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Sebastian BrählerDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Jan RiemerCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Redox Metabolism Group, Institute for Biochemistry, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Roman-Ulrich MüllerCologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Aleksandra TrifunovicFaculty of Medicine, University Hospital Cologne, Institute for Mitochondrial Diseases in Ageing, University of Cologne, Cologne, 50931, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, 50931, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Electronic address: aleksandra.trifunovic@uk-koeln.de.

Funding

Northwestern University Clinical & Translational Sciences Institute (NUCATS) 2.0U54TR001018 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2014 to 2014
$4.2M
NCATS NIH HHS U54 TR001018
6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (IRI) is initiated by a burst of mitochondrial reactive oxygen species generated when ischemia-accumulated succinate is rapidly oxidised upon reperfusion, driving reverse electron transport and triggering lipid peroxidation-dependent tubular cell death. Here, we identify the mitochondrial matrix protease CLPP as an unexpected regulator of renal redox resilience. CLPP deficiency reduced succinate-driven mitochondrial H

Indexed as

FerroptosisGlutathione metabolismLipid peroxidationMitochondrial CLPP proteaseMitochondrial dysfunctionNRF2Renal ischemia-reperfusion injuryRenal preconditioningSex differences

Identifiers

PMID42800460
PMCPMC13635565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.