Biocompatibility, Tissue Integration, and Angiogenic Potential of Polylactic Acid-Based Scaffolds in the Chicken Embryo Chorioallantoic Membrane Model.

A A Golubeva, A D Tsareva, I V Kholodenko, D V Klinov, D A Ivanov, P V Belousov, K N Yarygin

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A A GolubevaInstitute of Biomedical Chemistry, Moscow, Russia. yonag@yandex.ru.

A D TsarevaScientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Sirius Federal Territory, Russia.

I V KholodenkoInstitute of Biomedical Chemistry, Moscow, Russia.

D V KlinovScientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Sirius Federal Territory, Russia.

D A IvanovScientific Center for Genetics and Life Sciences, Sirius University of Science and Technology, Sirius Federal Territory, Russia.

P V BelousovEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

K N YaryginInstitute of Biomedical Chemistry, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of stem cells for the treatment of chronic wounds and burns is a promising trend in regenerative medicine. The efficacy of this approach largely depends on the cell delivery strategy. It is established that the use of polymeric scaffolds as cell carriers can, under certain conditions, facilitate integration of the graft into the host tissues and induce angiogenesis. We demonstrated that porous polylactide scaffolds induce pronounced perifocal vascularization with a minimal inflammatory response and the absence of fibrosis in the chorioallantoic membrane (CAM) model. Composite PLA/PCL structures additionally provide partial vascular ingrowth into the scaffold. At the same time, smooth PLA fibers demonstrated limited pro-angiogenic activity and induced perifocal fibrosis. Thus, matrix architecture is a crucial determinant of pro-angiogenic and general tissue responses, while porous scaffolds seem to be the most suitable for cell therapy of chronic wounds and burns.

Indexed as

angiogenesisbiocompatibilitychorioallantoic membrane (CAM)polylactide scaffoldsskin regeneration

Identifiers

PMID42799978

DOI10.3390/ijms241914813

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.