ArticleJournal of assisted reproduction and genetics2026
Predictive value of fresh and post-selection total motile sperm count on embryo quality and success rate of intracytoplasmic sperm injection in cycles with donated oocytes: a retrospective multi-center study.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study aims to evaluate whether fresh and post-selection total motile sperm count (TMSC) can be associated with embryo quality and cumulative live birth rate (CLBR) in intracytoplasmic sperm injection (ICSI) cycles. By focusing specifically on cycles using donated oocytes, the researchers aimed to minimize the confounding influence of female fertility factors.
methodsThis multicenter retrospective observational cohort study analyzed data from 862 couples undergoing ICSI with donated oocytes between January 2008 and December 2023 across 15 clinics in Spain. Patients were categorized into five distinct groups based on their fresh and post-selection TMSC values (ranging from less than 1 million to over 20 million). The primary outcome was CLBR, while secondary outcomes included fertilization rates, embryo quality, and pregnancy rates.
resultsWhile initial, unadjusted analyses showed some differences in fertilization rates and CLBR across the fresh TMSC groups, these associations lost statistical significance after adjusting for key confounding variables. Once adjustments were made for donor and male age, body mass index (BMI), sperm selection techniques, and WHO manual editions, neither fresh nor post-selection TMSC demonstrated any consistent, clinically meaningful relationship with fertilization, embryo quality, pregnancy outcomes, or CLBR.
conclusionsIn ICSI cycles using donor eggs, neither fresh nor post-selection TMSC was independently associated with reproductive outcomes once confounding factors are accounted for. Consequently, clinicians should recognize the limited prognostic value of conventional semen parameters such as TMSC when counseling couples and assessing reproductive outcomes in donor-oocyte ICSI cycles.
Indexed as
Identifiers
42799966What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.