ArticleAnnals of biomedical engineering2026
Peak-to-Peak Voltage Mapping Reveals Dynamic Arrhythmogenic Substrate Behavior in Isolated Rabbit Hearts.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cardiac arrhythmias are associated with structural and electrical remodeling processes that generate heterogeneous arrhythmogenic substrates characterized by low-voltage areas and abnormal conduction. Although electroanatomical voltage mapping is widely used for substrate characterization, epicardial voltage thresholds remain highly dependent on species, chamber, and recording configuration, and have not been systematically established for isolated rabbit hearts. We hypothesized that healthy rabbit epicardial tissue exhibits reproducible chamber-specific voltage distributions and that arrhythmias produce dynamic rhythm-dependent low-voltage areas substrate behavior. Isolated New Zealand White rabbit hearts (n = 9) were perfused using a Langendorff system and mapped using custom epicardial multi-electrode arrays. Unipolar EGMs were acquired from the right atrium (RA), left atrium (LA), and ventricular epicardium (V), while bipolar EGMs were derived from adjacent electrodes. Chamber-specific voltage thresholds were determined from sinus rhythm (SR) recordings using 95
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