Evidence map›Paper›PMID 42799910›Full record

ArticleBiogerontology2026

Perilla frutescens extract reduces fat accumulation and promotes longevity in Caenorhabditis elegans via modulation of the insulin/IGF-1 signaling pathway.

Lianghao Huang, Fengyu Yin, Xingdao Fu, Yurong Huang, Yixuan Tang, Guiyan Liao, Bin Wang, Ting Yang, Gang Huang, Xing Chen

Abstract read
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In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lianghao Huang *School of Public Health, Key Laboratory of Prevention and Control of Highly Prevalent Diseases (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, 530021, China.
Fengyu Yin *School of Public Health, Key Laboratory of Prevention and Control of Highly Prevalent Diseases (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, 530021, China.
Xingdao Fu *School of Public Health, Key Laboratory of Prevention and Control of Highly Prevalent Diseases (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, 530021, China.
Yurong HuangSchool of Public Health, Key Laboratory of Prevention and Control of Highly Prevalent Diseases (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, 530021, China.
Yixuan TangSchool of Public Health, Key Laboratory of Prevention and Control of Highly Prevalent Diseases (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, 530021, China.
Guiyan LiaoNational Key Laboratory of Non-Food Biomass Energy Technology, Guangxi Academy of Sciences, Nanning, 530007, China.
Bin WangNational Key Laboratory of Non-Food Biomass Energy Technology, Guangxi Academy of Sciences, Nanning, 530007, China.
Ting YangDepartment of Breast, Ren'ai Branch of the First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.
Gang HuangNational Key Laboratory of Non-Food Biomass Energy Technology, Guangxi Academy of Sciences, Nanning, 530007, China. wangyi.07@163.com.
Xing ChenSchool of Public Health, Key Laboratory of Prevention and Control of Highly Prevalent Diseases (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guangxi Medical University, Nanning, 530021, China. chenx63@163.com.

Funding

the Natural Science Foundation of Guangxi Zhuang Autonomous Region 2025GXNSFAA069604the Open Research Project of the State Key Laboratory of Non-food Biomass Energy Technology SKL-NFBET-2025-04
6 · The paper itself

Abstract

Perilla frutescens (PF) is rich in flavonoids and other secondary metabolites with antioxidant properties. This study explored the lifespan-modulating effects and underlying mechanisms of an ethyl acetate extract of PF leaves (EAEPF) using Caenorhabditis elegans (C. elegans) as a model organism. EAEPF treatment significantly prolonged lifespan, enhanced pharyngeal pumping and head thrashing frequencies, and reduced the accumulation of lipofuscin and reactive oxygen species (ROS). The extract improved antioxidant enzyme activity, decreased malondialdehyde (MDA) levels, and increased resistance to thermal and juglone-induced oxidative stress. EAEPF markedly reduced lipid storage in nematodes, indicating a lipid-lowering effect. Mechanistically, EAEPF activated the insulin/IGF-1 signaling (IIS) pathway, and upregulated the transcription factors DAF-16/FOXO and SKN-1/Nrf2, which in turn promoted the expression of downstream stress-response genes (sod-3, gst-4, hsp-16.2). EAEPF reprogrammed lipid metabolism and enhanced glutathione metabolism, may represent a potential source of nutritional hormetins. These findings demonstrated the potential of EAEPF as a nutraceutical for lifespan extension and healthspan improvement.

Indexed as

Caenorhabditis elegansInsulinInsulin-Like Growth Factor ILipid MetabolismLongevityPlant ExtractsSignal TransductionAnimalsAntioxidantsCaenorhabditis elegans ProteinsOxidative StressPlant LeavesReactive Oxygen SpeciesAntioxidantsCaenorhabditis elegans ProteinsInsulinInsulin-Like Growth Factor IPlant ExtractsReactive Oxygen SpeciesCaenorhabditis elegansHormesisHormetinInsulin/IGF-1 signalingLifespanLipid metabolismPerilla frutescens

Identifiers

PMID42799910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.