ArticleBrain structure & function2026
Thalamocortical white matter microstructure and cognition following mild traumatic brain injury: A fixel-based analysis.
Article in Brain structure & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The thalamus, an essential hub for cognitive integration across distributed brain networks, has emerged as a key structure implicated in mild traumatic brain injury (mTBI). However, while white matter microstructural injury is considered a core pathophysiological substrate of mTBI, few studies have examined thalamocortical microstructure following injury. The present study applied an advanced diffusion MRI-based white matter microstructural model, fixel-based analysis (FBA), to examine thalamocortical white matter microstructure and its associations with cognitive performance at approximately two-months following mTBI. The final analysed dataset included 39 mTBI patients and 28 trauma control (TC) patients aged 18-60 years, who were recruited following hospital admission for physical injury. Participants completed a range of cognitive tests and an MRI protocol including diffusion weighted sequences at 6-12 weeks following injury. Thalamocortical tracts were delineated bilaterally using the TractSeg algorithm, an automated white matter bundle segmentation tool. While whole-brain FBA showed no statistically significant differences in fixel metrics between groups, tract-based analyses showed that mTBI was associated with reduced fibre density (FD) of the right thalamo-precentral (BF
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