Evidence map›Paper›PMID 42799897›Full record

ArticleHuman genetics2026

A case-control study on IL-8 gene polymorphisms and serum IL-8 levels in patients with age-related macular degeneration in India.

Anshu Yadav, Jitender Phogat, Manoj Yadav, Aarti Bhardwaj, Vishal Panghal, Supreme Goel, Mamta Verma, Sapna Sharma, Mayank Singh, Rakesh Kumar and 1 more

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Article in Human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Anshu YadavDepartment of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Jitender PhogatRegional Institute of Ophthalmology, Sharma University of Health Sciences, Rohtak, Haryana, India.
Manoj YadavDepartment of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Aarti BhardwajDepartment of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Vishal PanghalDepartment of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India.
Supreme GoelRegional Institute of Ophthalmology, Sharma University of Health Sciences, Rohtak, Haryana, India.
Mamta VermaRegional Institute of Ophthalmology, Sharma University of Health Sciences, Rohtak, Haryana, India.
Sapna SharmaDepartment of Forensic Science, Maharshi Dayanand University, Rohtak, Haryana, India.
Mayank SinghMedical Oncology (Lab) Dr. B.R.A.I.R.C.H., All India Institute of Medical Sciences, New Delhi, India.
Rakesh KumarSchool of Biotechnology, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, India.
Mukesh TanwarDepartment of Genetics, Maharshi Dayanand University, Rohtak, 124001, Haryana, India. mukeshtanwar@mdurohtak.ac.in.ORCID https://orcid.org/0000-0003-0370-0371

Funding

Council for scientific and industrial research, New Delhi, India 09 /382(0244)/20 19- EM R-I
6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a leading cause of vision loss, with inflammatory and genetic factors contributing to its development. This study examined the association of IL-8 polymorphisms (rs4073, rs2227306, rs2227543) and serum IL-8 levels in a North Indian AMD cohort. A case-control study involving 160 AMD patients and 100 controls was performed. AMD was confirmed through detailed clinical evaluation and diagnostic imaging. Genomic DNA was extracted and genotyped using PCR followed by Sanger sequencing, and serum IL-8 concentrations were determined by ELISA. Statistical analyses were conducted using SPSS v22.0 and SNPstats. AMD patients exhibited significantly higher serum IL-8 levels than control (p < 0.001). ANCOVA adjusting for age and smoking confirmed elevated IL-8 in AMD (adjusted mean: 63.52 pg/ml vs. 41.23 pg/ml in controls; p < 0.001), with higher levels in wet AMD than dry AMD (67.75 pg/ml vs. 54.32 pg/ml; p = 0.043). The IL-8 rs4073 AA genotype and A allele were more frequent in AMD patients (p = 0.006 and p = 0.011, respectively). Multivariate logistic regression showed strong associations between rs4073 AA genotype and AMD risk under codominant (adjusted OR = 2.68; 95% CI: 1.17-6.15; p = 0.025), recessive (adjusted OR = 2.68; 95% CI: 1.27-5.67; p = 0.0067), and log-additive (adjusted OR = 1.50; 95% CI: 1.02-2.20; p = 0.036) models. No significant associations were observed for rs2227306 or rs2227543. Among all participants, AA carriers had significantly higher serum IL-8 levels than TT and AT genotypes (p = 0.018 and p < 0.001). The IL-8 rs4073 AA genotype and elevated serum IL-8 levels may serve as potential markers for AMD susceptibility in the North Indian population.

Indexed as

Interleukin-8Macular DegenerationPolymorphism, Single NucleotideAgedAllelesCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansIndiaMaleMiddle AgedCXCL8 protein, humanInterleukin-8

Identifiers

PMID42799897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.