Evidence map›Paper›PMID 42799824›Full record

ArticleNeuroscience bulletin2026

Terfa Safeguards GABAergic Inhibition and Neuronal Excitability in Zebrafish Through a Foxj3-Linked Transcriptional Mechanism.

Jialing He, Zhihong Song, Jiayi Zhang, Baoquan Zhao, Guo Bao, Nan Li, Changyong Zhang, Yuanyuan Ma, Marie Louise Groot, Tianqi Wang and 1 more

Abstract read
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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jialing He *Center of Laboratory Animal, National Research Institute for Family Planning, Beijing, 100081, China. hejialing@nrifp.org.cn.ORCID http://orcid.org/0009-0000-4118-3649
Zhihong Song *Academy of Military Medical Sciences, Beijing, 100850, China.
Jiayi ZhangNanjing Medical University, Nanjing, 210029, China.
Baoquan ZhaoState Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850, China.
Guo BaoCenter of Laboratory Animal, National Research Institute for Family Planning, Beijing, 100081, China.
Nan LiCenter of Laboratory Animal, National Research Institute for Family Planning, Beijing, 100081, China.
Changyong ZhangCenter of Laboratory Animal, National Research Institute for Family Planning, Beijing, 100081, China.
Yuanyuan MaDepartment of Physics, Vrije Universiteit Amsterdam, LaserLab Amsterdam, 1081 HV, Amsterdam, The Netherlands.
Marie Louise GrootDepartment of Physics, Vrije Universiteit Amsterdam, LaserLab Amsterdam, 1081 HV, Amsterdam, The Netherlands.
Tianqi WangCenter of Laboratory Animal, National Research Institute for Family Planning, Beijing, 100081, China. wangtianqi@nrifp.org.cn.
Bo ZhangKey Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University Genome Editing Research Center, Peking University, Beijing, 100871, China. bzhang@pku.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal hyperexcitability often results from impaired inhibition; however, the upstream regulators of GABAergic gene programs remain unclear. We identified a role for terfa, the zebrafish ortholog of human TERF2, in maintaining inhibitory tone and network stability. Homozygous terfa mutant larvae exhibit microcephaly, behavioral hyperactivity, and abnormal neuronal calcium dynamics, indicating a hyperexcitable state. Transcriptomic and RT-qPCR analyses showed coordinated downregulation of multiple GABA

Indexed as

Foxj3GABAA receptorGABAergic inhibitionNeuronal hyperexcitabilityTERF2/terfaZebrafish

Identifiers

PMID42799824

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.