ArticleFish physiology and biochemistry2026
Short-chain fatty acids alleviate metabolic disturbances induced by high-carbohydrate diets in largemouth bass (Micropterus salmoides).
Article in Fish physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the effects of dietary short-chain fatty acids (SCFAs) on carbohydrate metabolism in largemouth bass fed a high-carbohydrate diet. Juvenile fish (15.33 ± 0.14 g) were fed six isonitrogenous and isolipidic diets for 55 days, containing 10% (C, control), 15% (HC, high carbohydrate), and 20% (EC, extremely high carbohydrate) corn starch and three SCFA-supplemented diets based on the 15% carbohydrate diet level (0.2% sodium acetate (HC + A), propionate (HC + P), butyrate (HC + B)). High-carbohydrate diets significantly reduced growth performance increased hepatic lipid deposition and disrupted glucose homeostasis, with the EC diet inducing pronounced metabolic dysfunction characterized by reduced hepatic glycogen content and impaired insulin regulation. SCFA supplementation (sodium propionate and butyrate) restored weight gain and specific growth rate to C group levels, though no statistically significant difference was observed compared with the HC group. Notably, sodium butyrate significantly improved muscular quality by lowering crude lipid accumulation and increasing beneficial n-3 PUFA and DHA proportions. SCFA supplementation reduced the hepatosomatic index (HSI) and blood glucose levels and enhanced glycolysis, as indicated by increased pyruvate kinase activity and lactic acid levels, while suppressing gluconeogenesis through reductions in pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase activities. These metabolic benefits were associated with the upregulated expression of insulin receptor (ir) genes, rather than increased hormone secretion. Overall, dietary SCFAs, especially propionate and butyrate, effectively mitigate growth inhibition, hepatic lipotoxicity, and glucose metabolic disorders induced by high-carbohydrate diets, while simultaneously enhancing muscle nutritional value, demonstrating their high potential as functional feed additives in sustainable carnivorous fish aquaculture.
Indexed as
Identifiers
42799795What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.