ArticleNeurosurgical review2026
Tremor relief after gamma knife thalamotomy for Parkinson's disease.
Article in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinsonian tremor can remain disabling despite optimized medical therapy, impairing writing, drinking, feeding, and other activities of daily living. Gamma Knife radiosurgical (GKRS) thalamotomy is an incisionless surgical option for tremor patients who require chronic anticoagulation or have other major comorbidities for more invasive alternatives. We retrospectively evaluated the outcomes of 42 Gamma Knife thalamotomy procedures performed for medically refractory Parkinsonian tremor during the 1996 - 2020 interval. Outcomes parameters included clinical benefit, initial tremor relief, recurrence, motor functional improvement, and complications. Functional outcomes were assessed using Fahn-Tolosa-Marín (FTM) subscore composed of tremor, writing, drawing, and drinking domains. The median age at treatment was 76.5 years (IQR, 72.0-81.8), and median final follow-up was 14.0 months (IQR, 8.0-28.2). Clinical benefit occurred in 37 of 42 patients (88.1%), with a median time to onset of benefit of 4.0 months (IQR, 3.0-6.0). Tremor arrest occurred in 14 of 40 evaluable patients (35.0%), and complete arrest occurred in 10 of 40 (25.0%). The median total tremor-related FTM subscore improved from 12 before treatment to 4 after treatment, corresponding to a median relative improvement of 54.2% (p < 0.001). Temporary adverse effects occurred in 5 patients (11.9%). No definite tremor recurrence was documented. GKRS thalamotomy provides meaningful clinical benefit and significant tremor-related functional improvement with a low complication rate in selected patients with medically refractory Parkinsonian tremor. It remains a valuable incisionless surgical option for tremor-dominant Parkinson's disease when medical or more invasive therapies are unsuitable.
Indexed as
Identifiers
42799781What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.