ReviewRSC advances2026
Recent advances in metal-free functionalization of 1,4-benzoxazin-2-one scaffolds.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Transition metal free methodologies have emerged as sustainable alternatives for the functionalization of biologically important heterocylic scaffolds. Among the heterocycles 1,4-benzoxazin-2-one has attracted considerable interest owing to its diverse pharmaceutical and agrochemical applications. In this review, we summarize the recent advances in the transition metal-free functionalization of 1,4-benzoxazin-2-one, highlighting the organocatalytic transformations, main group Lewis acid/base promoted reactions, visible-light mediated and ultrasound assisted multicomponent reactions. Special emphasis is given to methodologies that enable the efficient synthesis of biologically active 1,4-benzoxazin-2-one derivatives. The reaction scope, mechanistic aspect, regio and stereoselectivity, and synthetic applications of these methodologies are critically discussed to provide a comprehensive overview of this rapidly developing area.
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Registered trials
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