Evidence map›Paper›PMID 42799354›Full record

ArticleChemSusChem2026

The Natural Product Esculetin as an Efficient Photoacid for the Visible-Light-Mediated Acetalization/Ketalization Reaction.

Maria A Theodoropoulou, E Alexandros Routsi, Christiana Mantzourani, Olga G Mountanea, Demeter Tzeli, Christoforos G Kokotos, George Kokotos

Abstract read
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In one paragraph

Article in ChemSusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria A TheodoropoulouLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-6552-5217
E Alexandros RoutsiLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0009-0002-6857-2382
Christiana MantzouraniLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-2621-1231
Olga G MountaneaLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-4669-2818
Demeter TzeliLaboratory of Physical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-0899-7282
Christoforos G KokotosLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-4762-7682
George KokotosLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0003-3753-7082

Funding

Hellenic Foundation for Research and Innovation 21044Hellenic Foundation for Research and Innovation 655
6 · The paper itself

Abstract

The development of photochemical protocols for the production of fine chemicals and industrially interesting products, employing sustainable catalysts under mild conditions, is of high interest. We demonstrate herein that esculetin, a naturally occurring coumarin widespread in plants, is an efficient photoacid, catalyzing acetalization/ketalization reactions under visible light irradiation. A variety of aldehydes and alcohols produce acetals in high yields, using a low catalyst loading of esculetin under 427-nm LED irradiation. In addition, various ketals, including industrially interesting products, such as solketal, fructone, and levulinate-based ketals, are generated in high yields. Esculetin has been proven to be an excellent, efficient photocatalyst for the production of acetals and ketals under mild and environmentally friendly conditions, highlighting that natural products offer a platform for investigation in an effort to discover sustainable renewable photocatalysts.

Indexed as

acetalizationesculetinketalsphotoacidvisible light photocatalysis

Identifiers

PMID42799354
PMCPMC13615548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.