ArticleCureus2026
Hyperemesis Gravidarum and the Genetics of Growth Differentiation Factor 15 (GDF-15): A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperemesis gravidarum (HG), the extreme form of nausea and vomiting during pregnancy, significantly impacts the quality of life of a subset of pregnant individuals, leading to hospitalization and severe health complications. Despite the prevalence and intensity of HG, therapeutic approaches remain largely palliative, focusing on symptom management without addressing the underlying pathophysiology. This report delineates a case of severe HG in a 31-year-old woman, highlighting the complexity of diagnosis and management, and discusses the potential of growth differentiation factor 15 (GDF-15) as a therapeutic target. GDF-15, a biomarker linked to placental development and appetite regulation, emerges as a promising avenue for understanding and potentially treating HG. By exploring GDF-15's role in HG, this case report emphasizes the need for further research into the genetic and biological mechanisms underlying HG. Additional research on HG may facilitate the development of improved management strategies that are both effective for the mother and safe for the fetus.
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