ArticleInfection and drug resistance2026
Application of NGS Technology in Osteomyelitis Caused by Human Bites.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Osteomyelitis caused by human bites is a severe and complex polymicrobial infection that is often complicated by delayed diagnosis and the high false-negative rate of conventional cultures. This case series retrospectively analyzed four cases of human bite-induced osteomyelitis to evaluate the clinical utility of next-generation sequencing (NGS) for the diagnosis of complex infections. Conventional intraoperative bacterial cultures were negative in two of the four cases, limiting pathogen-directed antimicrobial therapy. In contrast, NGS identified microbial organisms in all four patients and revealed polymicrobial profiles in several cases, including fastidious oral flora and obligate anaerobes that were not detected by conventional culture, such as
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