Evidence map›Paper›PMID 42799126›Full record

ArticleACS central science2026

Spatially Resolved Photostimulation of Cardiac Activity Using Optoelectronic Peptides.

Emil M Lundqvist, Krystal Nguyen, Caleb O Chung, Sheng Wei Tang, Natalie Celt, Harrison C Jeong, Sujeung Lim, Lanie Le, Kathryn K Lee, Kenneth O Chua and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emil M LundqvistDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92617, United States.ORCID https://orcid.org/0009-0000-2126-0926
Krystal NguyenDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92617, United States.ORCID https://orcid.org/0009-0000-7312-3974
Caleb O ChungDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92617, United States.
Sheng Wei TangDepartment of Chemistry, University of California Irvine, Irvine, California 92617, United States.
Natalie CeltDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92617, United States.
Harrison C JeongDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92617, United States.
Sujeung LimDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92617, United States.
Lanie LeDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92617, United States.
Kathryn K LeeDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92617, United States.
Kenneth O ChuaDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Alessandra Mandala KolDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Jayden R StahlDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Skylar R FoustDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92617, United States.
Yuyao KuangDepartment of Chemical and Biomolecular Engineering, University of California Irvine, Irvine, California 92617, United States.ORCID https://orcid.org/0000-0003-2639-3116
Megan N JacksonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.ORCID https://orcid.org/0000-0002-7978-5212
Herdeline Ann M ArdoñaDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92617, United States.ORCID https://orcid.org/0000-0003-0640-1262

Funding

Optically Promoting Cardiac Maturation Using Engineered PeptidesR01HL164348 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Herdeline Ann Mallari Ardona · 2023 to 2026
$2.3M
Multiphoton Microscope for Cardiovascular and Tissue EngineeringS10OD025064 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2019 to 2019
$595k
NHLBI NIH HHS R01 HL164348NIH HHS S10 OD025064
6 · The paper itself

Abstract

Engineering physiologically relevant cardiac substrates requires precise control over both electrical and mechanical cues to guide cardiomyocyte functions and features. In this work, we report a biomolecular-based approach toward spatially controllable photostimulation of cardiac behavior via digital light processing of conductive interfaces on a range of substrate stiffnesses. The symmetric peptide-quaterthiophene-peptide units are designed to form conductive patterns atop biopolymeric hydrogels, allowing for microscale spatial control of photoconductive pathways that can influence cardiomyocyte alignment and intercellular communication in a light-activated manner. Substrate stiffness was modulated through adjusting material composition across a physiologically relevant range to reflect healthy and fibrotic cardiac tissue conditions. The ability to tailor the geometry of conductive pathways across a range of biomaterial interfaces and stiffnesses enables systematic assessment of how electrical signals from patterned optoelectronic peptides regulate cardiomyocyte behavior. Neonatal rat ventricular myocytes (NRVMs) cultured on π-conjugated peptide-based substrates exhibited enhanced alignment, synchronous contractility, and altered calcium flux dynamics compared to nonconductive substrates. Furthermore, the optoelectronic cardiac biomaterial-based scaffolds were shown to possess biological photostimulation capabilities, specifically enabling light-induced localized stimulation of excitable cells for high-resolution stimulation without the need for external electrodes or genetic modifications necessary for optogenetic approaches. Photostimulated NRVMs interfaced with optoelectronic peptide structures were shown to be more confined to the printed conductive patterns, with more cell localization and structural remodeling with respect to the patterns than in non-photostimulated conditions. The peptide-based platform presented here provides a potential approach to control mechanical and optoelectronic cues using microscale patterns

Identifiers

PMID42799126
PMCPMC13614055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.