Evidence map›Paper›PMID 42799091›Full record

ReviewRSC chemical biology2026

Targeting virus-glycan recognition in influenza viruses and coronaviruses: from the molecular principles to glycomimetic antivirals strategies.

Cristina Fernández-Pérez, María Emilia Cuervo, Iris A Bermejo, Jon Imanol Quintana, Ana Gimeno, Ana Ardá, Jesús Jiménez-Barbero, Luca Unione

Abstract readReview
In one paragraph

Review in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristina Fernández-PérezCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.
María Emilia CuervoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.
Iris A BermejoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.
Jon Imanol QuintanaCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.
Ana GimenoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.
Ana ArdáCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.
Jesús Jiménez-BarberoCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.ORCID https://orcid.org/0000-0001-5421-8513
Luca UnioneCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA) 48160 Derio Bizkaia Spain jjbarbero@cicbiogune.es lunione@cicbiogune.es.ORCID https://orcid.org/0000-0002-8724-8783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycans constitute the first molecular landscape encountered by viruses during infection and play fundamental roles in viral attachment, host adaptation, tissue tropism, and immune evasion. Far from being passive components of the cell surface, host glycans actively regulate virus-host interactions by functioning as attachment factors, entry receptors, or modulators of receptor engagement, while viral glycans contribute to immune escape and infectivity. Consequently, the molecular recognition of glycans has emerged as a major determinant of viral evolution and pathogenicity. This review presents our perspective on the structural and mechanistic principles that govern virus-glycan recognition, focusing on influenza viruses and coronaviruses as paradigmatic examples. We discuss how subtle variations in glycan structure, including glycosidic linkage, chain length, multivalent presentation, and chemical modifications such as

Identifiers

PMID42799091
PMCPMC13613654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.