ReviewObesity pillars2026
Investigating seizures in bariatric surgery patients: Pre- and postoperative perspectives: A systematic review.
Review in Obesity pillars, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Bariatric surgery is widely used for severe obesity and may influence neurological outcomes through metabolic alterations, nutritional deficiencies, and changes in Antiepileptic Drug (AED) absorption. Despite increasing reports of neurological complications, seizure patterns before and after bariatric surgery have not been comprehensively summarized. Methods: This was a systematic review conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search of PubMed, Scopus, Web of Science, and Embase was conducted through April 20, 2025. Eighty-three studies reporting seizures before and/or after bariatric surgery were included. Data on patient demographics, surgery type, seizure timing, etiology, AED adjustments, and clinical outcomes were narratively synthesized. Results: Across the included studies, patients were mostly middle-aged women undergoing sleeve gastrectomy or Roux-en-Y gastric bypass. Three outcome patterns emerged. Some patients with pre-existing epilepsy remained seizure-free postoperatively with stable AED regimens. Others experienced persistent or recurrent seizures, commonly associated with reduced postoperative absorption of valproate or phenytoin, requiring dose escalation or drug substitution. New-onset postoperative seizures occurred across both surgery types and were predominantly secondary to metabolic disturbances especially hypoglycemia, hyperammonemia, electrolyte abnormalities, or cardiac arrhythmia and typically resolved after addressing the underlying cause. AED adjustments were more frequently required after gastric bypass due to greater pharmacokinetic changes. Conclusion: Seizure outcomes after bariatric surgery are variable and influenced by altered drug absorption and postoperative metabolic complications. Most patients maintain seizure control, but a subset develops breakthrough or new-onset seizures, highlighting the need for AED monitoring and careful evaluation of metabolic causes.
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