Evidence map›Paper›PMID 42799026›Full record

ArticleAtherosclerosis plus2026

Putative protective role of

Sonia Rodríguez-Nóvoa, Pedro Martínez Hernández, Irene Hidalgo Mayoral, Amanda Herranz Cecilia, Neila Rodríguez Roca, Ana Carazo Álvarez, Natividad Gallego Onís, Marta Duque Alcorta, Carmen Rodríguez Jiménez

Abstract read
In one paragraph

Article in Atherosclerosis plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sonia Rodríguez-NóvoaSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.
Pedro Martínez HernándezDepartment of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain.
Irene Hidalgo MayoralSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.
Amanda Herranz CeciliaSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.
Neila Rodríguez RocaSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.
Ana Carazo ÁlvarezSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.
Natividad Gallego OnísSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.
Marta Duque AlcortaDepartment of Clinical Laboratory, Hospital Universitario La Paz, Madrid, Spain.
Carmen Rodríguez JiménezSection of Genetics of Metabolic Diseases, Genetic Service. Hospital Universitario La Paz, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Familial hypercholesterolemia (FH) is most frequently caused by pathogenic variants in Methods: We investigated a large multigenerational family with FH, combining clinical data, lipid profiles, and genetic analysis with functional studies. Results: The Conclusions: These findings suggest the potential relevance of investigating gene-gene interactions and variants with opposing effects on the lipid phenotype in FH. Integrating clinical, biochemical, genetic, and functional data may help explain intrafamilial variability and support more precise interpretation of inherited dyslipidemias.

Indexed as

APOBFamilial hypercholesterolemiaGenetic modifiersLDLRPCSK9

Identifiers

PMID42799026
PMCPMC13613513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.