Evidence map›Paper›PMID 42798874›Full record

ArticleBrain communications2026

Unbiased bioinformatic and clinical analysis identifies glial fibrillary acidic protein as a potential biomarker in spinal muscular atrophy.

Karina Lúcia Soares de Oliveira, Arthur Carpeggiani Weber, Michele Michelin Becker, Juliana Silva de Almeida Magalhães, Ana Letícia Amorim de Albuquerque, Júlia Kersting Chadanowicz, Giovanna Câmara Giudicelli, Francieli Rohden, Eduardo Rigon Zimmer, Thayne Woycinck Kowalski and 3 more

Abstract read
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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karina Lúcia Soares de OliveiraGraduate Program in Medicine, Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035003, Brazil.
Arthur Carpeggiani WeberClinical Neurogenetics Research Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035903, Brazil.
Michele Michelin BeckerChild Neurology Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035903, Brazil.
Juliana Silva de Almeida MagalhãesNeuromuscular Disease Center, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA 40285001, Brazil.
Ana Letícia Amorim de AlbuquerqueGraduate Program in Medicine, Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035003, Brazil.
Júlia Kersting ChadanowiczClinical Neurogenetics Research Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035903, Brazil.
Giovanna Câmara GiudicelliBioinformatics Core, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035903, Brazil.
Francieli RohdenGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil.
Eduardo Rigon ZimmerGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035-003, Brazil.
Thayne Woycinck KowalskiBioinformatics Core, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035903, Brazil.
Marina SiebertUnit of Laboratorial Research, Experimental Research Center, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS 90035903, Brazil.
Marcela Câmara Machado CostaNeuromuscular Disease Center, Escola Bahiana de Medicina e Saúde Pública, Salvador, BA 40285001, Brazil.
Jonas Alex SauteGraduate Program in Medicine, Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035003, Brazil.ORCID https://orcid.org/0000-0003-1141-6573

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by bi-allelic pathogenic variants in

Indexed as

biomarkerdifferential gene expressionGFAPneurofilament light chainspinal muscular atrophy

Identifiers

PMID42798874
PMCPMC13613212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.