ReviewCureus2026
The Human Hyoid Body-Greater Cornu Junction: Development, Histological Diversity, and Imaging Correlates.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human hyoid develops from anatomically distinct components, yet in anatomical, radiological, and forensic reports, the body-greater cornu junction is often reduced to a binary fused/unfused state. This structured narrative review with critical appraisal evaluates human evidence concerning embryological development, postnatal ossification, histological organization, age-related junctional union, and imaging interpretation of this interface. PubMed/MEDLINE and Google Scholar were searched through July 2026 using combinations of terms related to the hyoid bone, development, embryology, ossification, fusion, nonfusion, synostosis, synchondrosis, histology, and computed tomography; reference lists of relevant studies were also examined. Human serial-embryological, cadaveric, histological, radiographic, CT, three-dimensional CT, and micro-CT studies were prioritized. Because study populations, definitions of fusion, age strata, imaging resolution, and side-level versus person-level units of analysis were insufficiently harmonized, the evidence was synthesized narratively rather than pooled quantitatively. Direct human embryological observations support a spatially distinct median hyoid-body condensation but do not establish cellular lineage. Postnatal ossification of the body and greater cornua is distinct from subsequent remodeling and possible union of their interface. In adults, the junction may remain cartilaginous or joint-like, exhibit peripheral mineralization, develop partial osseous bridging, or undergo complete synostosis. These configurations represent distinct observed states and should not be assumed to constitute an obligatory longitudinal sequence. Junctional union becomes more frequent with age, but complete synostosis may occur in young adults, whereas nonfusion may persist into advanced age. Radiographic approximation, sclerosis, or marginal mineralization should therefore not be equated automatically with histologically complete osseous continuity. A provisional four-category operational framework is proposed to improve consistency across anatomical, imaging, and forensic studies. Future research should prioritize same-specimen correlation of standardized thin-section CT, micro-CT, and histology in independently documented, age-balanced human material.
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