Evidence map›Paper›PMID 42798836›Full record

ArticleOncology letters2026

Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics.

Lien-Cheng Tsao, Chen-Ling Kuo, Yu-Shan Cheng, Ching-Shan Huang, Chin-San Liu, Shih-Li Su

Abstract read
In one paragraph

Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lien-Cheng TsaoDepartment of Surgery, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.
Chen-Ling KuoVascular Medicine and Diabetes Research Center, Institute of ATP, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.
Yu-Shan ChengVascular Medicine and Diabetes Research Center, Institute of ATP, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.
Ching-Shan HuangVascular Medicine and Diabetes Research Center, Institute of ATP, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.
Chin-San LiuCenter of Regenerative Medicine and Tissue Repair, Institute of ATP, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.
Shih-Li SuVascular Medicine and Diabetes Research Center, Institute of ATP, Changhua Christian Hospital, Changhua 50006, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated potential plasma biomarkers associated with cancer risk and mortality in patients with type 2 diabetes mellitus (T2DM), a population known to have an increased cancer incidence and poorer outcomes compared with non-diabetic individuals. Traditional metabolic indicators, including blood pressure, blood glucose and blood lipids, have limited predictive value for cancer risk, highlighting the need for novel clinical biomarkers. In total, 141 subjects with T2DM were enrolled in this study. Plasma inflammatory and lipid-related biomarkers included cluster of differentiation 147 (CD147), cyclophilin A (CyPA), cytokines, oxidized low-density lipoprotein (oxi-LDL), oxi-LDL antibody and proprotein convertase subtilisin/kexin type 9 (PCSK9). Among all participants, 37.6% were obese (body mass index ≥27 kg/m

Indexed as

cancer predictive biomarkerCD147diabetesobesityPCSK9

Identifiers

PMID42798836
PMCPMC13613195

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.