ArticleFrontiers in neurology2026
Posterior reversible encephalopathy syndrome (PRES) in children - a summary of 20 years of tertiary neurology centre experience.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological syndrome characterised by seizures, hypertension, visual disturbances alongside classical parieto-occipital lesions on neuroimaging. We report the clinical presentation and management of the largest UK paediatric PRES cohort. Methods: Seventy-seven children (x̄ age = 8.6 years [SD = 4.3], 64% male) experienced PRES as inpatients at Great Ormond Street Hospital (London, UK) from January 2005 to May 2024. Electronic patient records were retrospectively analysed. Results: Most children (97.4%) had significant co-morbidities, including haem-oncological ( Conclusion: Our cohort showcases the broad clinical spectrum of paediatric PRES. Global standardised clinical pathways are needed to better inform both acute and long-term management and outcomes.
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