ReviewInternational journal of dentistry2026
Current Developments in Antibacterial Nanoparticle-Based Dental Composite Materials: A Comprehensive Overview.
Review in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistence of secondary caries, biofilm accumulation, and hybrid layer degradation as leading causes of failure in resin-based composite (RBC) restorations underscores the urgent need for materials that can effectively prevent demineralization and promote the remineralization of dental hard tissues. Conventional composites are primarily bioinert, offer minimal defense against cariogenic biofilms, and lack the ability to restore mineral loss at the tooth-restoration interface. Recent advancements in nanotechnology have paved the way for the development of antibacterial and bioactive composites that integrate metallic, metal-oxide, polymeric, organic, and ion-releasing nanoparticles (NPs). These innovative systems provide antimicrobial effects through contact or ion-mediated mechanisms, enhance the stability of the hybrid layer, and increasingly demonstrate potential for remineralization through the controlled release of calcium, phosphate, or fluoride ions. This review provides a critical analysis of the current antibacterial bioactive resin-based nanocomposites employed in dentistry, covering the PubMed, Scopus, Web of Science, and Google Scholar databases with keywords silver (Ag), zinc oxide, titanium dioxide, and magnesium oxide NPs (MgO-NPs); quaternary ammonium polyethylenimine (QA-PEI)-based systems; chitosan-derived NPs; and remineralization-promoting fillers such as bioactive glass (BG) and primarily covering studies published between 2020 and 2026. Key challenges, including NP agglomeration, aesthetic modifications, variable biocompatibility, uncontrolled ion release, and the absence of standardized evaluation protocols, are examined in relation to their impact on predictable remineralization and clinical outcomes. Most current evidence remains preclinical, with limited in situ and early translational validation. This comprehensive narrative review included studies investigating NP-modified dental restorative materials and excluded duplicate records, nondental applications, and studies not relevant to restorative dentistry.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.