ReviewO&G open2026
Peri-delivery Calcium Administration and Postpartum Bleeding: A Systematic Review and Meta-analysis.
Review in O&G open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether peri-delivery administration of exogenous calcium improves postpartum bleeding outcomes. DATA SOURCES: We conducted a systematic review of randomized controlled trials (RCTs) and quasi-randomized trials comparing pregnant individuals undergoing vaginal or cesarean delivery who received exogenous calcium before or within 1 hour of delivery with those who received no calcium supplementation. We searched Ovid MEDLINE, Ovid EMBASE, CINAHL, Scopus, Web of Science, and CENTRAL/The Cochrane Library (including ClinicalTrials.gov) from inception through July 10, 2025 (PROSPERO 2025 CRD420251091214). METHODS OF STUDY SELECTION: Titles, abstracts, and full texts were independently screened in duplicate. Six RCTs and one quasi-randomized study including 806 participants (403 intervention, 403 control) were included. All participants underwent cesarean delivery. Interventions included intravenous calcium chloride or calcium gluconate, administered after delivery, after cord clamping, or perioperatively. TABULATION INTEGRATION AND
resultsThe primary outcome was estimated or quantitative postpartum blood loss. Secondary outcomes included the use of additional uterotonics beyond prophylactic oxytocin and other postpartum bleeding-related outcomes. Random-effects models were used to calculate ratio of means, pooled mean differences, and risk ratios (RRs) with 95% CIs. Calcium supplementation was associated with 8% lower postpartum blood loss compared with control (ratio of means 0.92, 95% CI, 0.88-0.97). Calcium supplementation was associated with a lower frequency of additional uterotonic use (27.1%) compared with controls (41.9%) (RR 0.69, 95% CI, 0.49-0.96). Low-to-moderate heterogeneity was observed, and most studies were judged to be at low risk of bias.
conclusionPeri-delivery calcium administration was associated with reduced postpartum blood loss and decreased need for additional uterotonics. Although effect sizes were modest and evidence was limited by few studies and heterogeneity in calcium formulations and doses, these findings suggest that calcium may enhance uterine contractility. Larger RCTs are needed to confirm efficacy and to determine optimal dosing. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD420251091214.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.