ArticleFrontiers in bioengineering and biotechnology2026
Two-dimensional data storage using a DNA molecular register.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Existing molecular data-storage systems still mainly encode information along one-dimensional chemical sequences or linear molecular coordinates, leaving the spatial addressability of molecular architectures insufficiently explored. Here we report a physical two-dimensional DNA molecular register, termed a spatially addressable molecular breadboard (SAMB), in which digital bits are assigned to predefined molecular coordinates rather than to positions along a one-dimensional sequence. SAMB is built by hierarchical assembly of DNA origami single modules into a globally registered two-dimensional address space. In this register, each data or parity bit is encoded by the presence or absence of streptavidin at a defined coordinate site and read out from local topographic height differences, whereas the fiducial marker (FM) site defines register orientation and coordinate alignment. As a proof of concept, we encode a Petersen graph payload in a 49-coordinate SAMB register and demonstrate
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