Evidence map›Paper›PMID 42798601›Full record

ArticleFrontiers in immunology2026

Heat-killed

Gülce Bıçakcıoğlu, Laura Bravo-Robles, Pablo Mata-Martínez, Jaime Fernández, Verónica Terrón-Arcos, Natalia González, Inés Rubio, Rebeca Abad-Moret, Sylwia Bilas, Esteban Díaz and 3 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gülce BıçakcıoğluThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.
Laura Bravo-RoblesThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.
Pablo Mata-MartínezThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.
Jaime FernándezThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.
Verónica Terrón-ArcosThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.
Natalia GonzálezGeneral and Digestive Surgery Service, La Paz University Hospital, Madrid, Spain.
Inés RubioGeneral and Digestive Surgery Service, La Paz University Hospital, Madrid, Spain.
Rebeca Abad-MoretGeneral and Digestive Surgery Service, La Paz University Hospital, Madrid, Spain.
Sylwia BilasGeneral and Digestive Surgery Service, La Paz University Hospital, Madrid, Spain.
Esteban DíazGeneral and Digestive Surgery Service, La Paz University Hospital, Madrid, Spain.
Ramón Cantero-CidGeneral and Digestive Surgery Service, La Paz University Hospital, Madrid, Spain.
Eduardo López-CollazoThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.
Carlos Del FresnoThe Innate Immune Response Group, IdiPAZ, La Paz University Hospital, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Trained immunity (TI) is a form of innate immune memory characterized by boosted innate immune responses to secondary heterologous challenges following an initial stimulus. Several inducers, including fungal β-glucan and the Bacillus Calmette-Guérin (BCG) vaccine, induce TI in human peripheral blood mononuclear cells (PBMCs). Although the potential of TI in colon cancer has been explored in murine models, its relevance in patients remains poorly understood. Methods: Building on our previous demonstration that heat-killed Results: HK Conclusion: These findings provide proof of concept that HK

Indexed as

Colonic NeoplasmsLeukocytes, MononuclearMycobacterium tuberculosisProgrammed Cell Death 1 ReceptorTrained ImmunityAgedBacterial LysatesCell Line, TumorCytokinesFemaleHot TemperatureHumansImmune Checkpoint InhibitorsMaleMiddle AgedBacterial LysatesCytokinesImmune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 Receptoranti-PD-1colon cancerHKMtbimmunotherapytrained immunity

Identifiers

PMID42798601
PMCPMC13612437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.