Evidence map›Paper›PMID 42798576›Full record

SynthesisFrontiers in psychology2026

Modulation of cognitive and motor functions by temporal interference stimulation: a systematic review and meta-analysis of efficacy and variability.

Samaneh Aziziaram, Anna Elisabeth Fromm, Inês R Violante, Agnes Flöel, Daria Antonenko

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samaneh AziziaramDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Anna Elisabeth FrommDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Inês R ViolanteSchool of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom.
Agnes FlöelDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Daria AntonenkoDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporal interference stimulation (TIS) is a non-invasive brain stimulation technique proposed to focally modulate both cortical and subcortical brain regions. A growing number of human studies have examined its effects on cognitive and motor performance, but inconsistent findings across heterogeneous protocols leave its overall behavioral efficacy uncertain. We conducted the first meta-analysis of TIS in humans, quantifying both its behavioral efficacy and the variability of responses across studies. Following PRISMA 2020 guidelines, we systematically searched PubMed, Web of Science, and Embase for human

Indexed as

meta-analysisnon-invasive brain stimulationresponse variabilitystimulation effecttemporal interference stimulation (TIS)transcranial electrical stimulation (tES)

Identifiers

PMID42798576
PMCPMC13612444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.