ReviewResearch in heart yield and translational medicine2025
Reduced Left Ventricular Global Longitudinal Strain in the Coronary Slow Flow Phenomenon: A Systematic Review and Meta-Analysis.
Review in Research in heart yield and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Critical Appraisal of a Recently Published Systematic Review.Research in heart yield and translational medicine · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highlights: CSFP is associated with a significant reduction in left ventricular global longitudinal strain (LVGLS) despite preserved left ventricular ejection fraction (LVEF).Layer-specific strain analysis reveals the most pronounced impairment in the endocardial layer.LVGLS demonstrates moderate-to-high diagnostic accuracy for detecting CSFP (pooled AUC: 0.80).These findings support LVGLS as a noninvasive marker of subclinical myocardial dysfunction in CSFP. Background: The coronary slow flow phenomenon (CSFP) involves delayed coronary artery filling without obstruction and is associated with angina and myocardial ischemia. This meta-analysis assessed the link between CSFP and impaired left ventricular global longitudinal strain (LVGLS), a marker of subclinical myocardial dysfunction. Methods: A systematic search (PubMed, Embase, Scopus up to January 2025) identified 18 observational studies comparing LVGLS and layer-specific strain in patients with CSFP vs controls with normal coronary flow. Results: Patients with CSFP showed significantly reduced LVGLS vs controls (SMD, 1.22; 95% CI, 0.69 to 1.75). Layer-specific analysis revealed impairment across all myocardial layers, most pronounced in the endocardium (SMD, 0.79; 95% CI, 0.21 to 1.38). While left ventricular ejection fraction (LVEF) was preserved, LVGLS demonstrated moderate-to-high diagnostic accuracy for CSFP (AUC, 0.80; 95% CI, 0.66 to 0.95). Reduced LVGLS independently predicted CSFP (adjusted OR, 1.43; 95% CI, 1.19 to 1.46). Exercise stress effects on LVGLS were inconsistent. Conclusion: CSFP is associated with impaired LVGLS, particularly in the endocardial layer, despite preserved LVEF. LVGLS may serve as a noninvasive marker for subclinical dysfunction in CSFP.
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