ArticleFrontiers in cellular and infection microbiology2026
Clinical significance of
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Persistent high-risk HPV infection is the major cause of cervical carcinogenesis, but the clinical relevance of Methods: This retrospective study included 21,275 outpatients who underwent concurrent HPV genotyping, CT PCR testing, and cytological or histopathological evaluation between 2015 and 2024. Age-specific patterns and temporal trends were assessed. Age-adjusted logistic regression was used to examine associations of HPV and CT with cervical lesion categories. Six DNA methylation markers were analyzed in a subset of samples. Results: Overall prevalence was 25.7% for HPV, 8.7% for CT, and 3.8% for HPV-CT coinfection, with declining trends over time. CT infection and HPV-CT coinfection were more common in younger women. HPV positivity was significantly higher in CT-positive than CT-negative women (43.9% vs 23.9%, Conclusions: CT infection and HPV-CT coinfection were concentrated in younger women and were more frequently associated with low-grade cervical abnormalities. CT positivity was also associated with a higher prevalence of HPV infection.
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