Evidence map›Paper›PMID 42798358›Full record

ArticleFrontiers in immunology2026

Antimicrobial peptide Pt5-1c exerts potent immunomodulatory and antiviral effects by facilitating cellular delivery of cGAMP.

Xuelian Zhao, Zetao Ding, Jingwei Zhang, Shuran Yang, Yang Zhu, Yuan Tang, Hao Wang, Beibei Chen, Chanyuan Guo, Rijun Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xuelian ZhaoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Zetao DingState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Jingwei ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Shuran YangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yang ZhuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yuan TangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Hao WangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Beibei ChenState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Chanyuan GuoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Rijun ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Dayong SiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Xubiao WeiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cGAS-STING signaling axis constitutes a pivotal defense mechanism in innate immunity, where the second messenger cyclic 2', 3'-GMP-AMP (hereafter referred to as cGAMP) orchestrates the induction of type I interferons (IFNs) to combat viral infections. Despite its therapeutic potential, the clinical translation of cGAMP is severely hampered by its intrinsic physicochemical properties-high hydrophilicity and polyanionic charge-which result in poor membrane permeability and suboptimal bioavailability. Here, we identify Pt5-1c, a zebrafish phosvitin-derived antimicrobial peptide, as a potent immunomodulatory agent that overcomes this delivery bottleneck. Our results demonstrate that Pt5-1c significantly amplifies cGAMP-mediated immune signaling by enhancing its extracellular availability. Mechanistically, Microscale Thermophoresis (MST) and LC-MS/MS analyses reveal that Pt5-1c directly complexes with cGAMP, facilitating its efficient delivery to target cells, thereby triggering a robust STING-dependent cascade and downstream effector expression. In both

Indexed as

Antimicrobial Cationic PeptidesAntimicrobial PeptidesAntiviral AgentsNucleotides, CyclicAnimalscGAS-STING Signaling PathwayHumansImmunity, InnateInterferon Type IMembrane ProteinsSignal TransductionSTING ProteinZebrafishAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntiviral Agentscyclic guanosine monophosphate-adenosine monophosphateInterferon Type IMembrane ProteinsNucleotides, CyclicSTING Proteinantimicrobial peptideantiviral effectscGAMPcGAS-STING signalingimmunology

Identifiers

PMID42798358
PMCPMC13612190

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.