Trial reportMedical science monitor : international medical journal of experimental and clinical research2026
Effect of Multi-Modal Training in Patients With Mild Cognitive Impairment: A Randomized Controlled Pilot Trial.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND This study aimed to evaluate whether a multi-modal training that combined Baduanjin, computerized cognitive training, and reminiscence therapy is associated with improved cognitive function in older adults with mild cognitive impairment (MCI) in a pilot randomized controlled trial. MATERIAL AND METHODS Sixty-five patients with MCI were randomly assigned into an intervention group (a 24-week multi-modal training) and a control group (health education). Cognitive function was assessed at baseline, week 12, and week 24 using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). A repeated-measures ANOVA was conducted across 3 time points to examine the group effects, time effects, and interactions. RESULTS Significant group × time interactions were observed for MMSE and MoCA (both P<0.001). At 24 weeks, the intervention group showed greater improvement than the control group in MMSE score, with a between-group difference of 1.88 points (P<0.001), and in MoCA score, with a between-group difference of 1.62 points (P<0.001). Exploratory MoCA subdomain analyses suggested possible domain-specific benefits in the intervention group, with nominal declines in naming, memory, and attention in controls. CONCLUSIONS This pilot randomized controlled trial provides preliminary evidence that a 24-week multi-modal program combining Baduanjin, computerized cognitive training, and reminiscence therapy was associated with improved global cognitive performance in community-dwelling older adults with MCI compared with health education alone. Given the pilot nature of the study and the modest between-group differences, these findings should be interpreted with caution and confirmed in larger, adequately powered trials.
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