ArticleVeterinary sciences2026
Modeling Canine Hemangiosarcoma Progression Using Patient-Derived 2.5D Organoids and Orthotopic Xenografts.
Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Canine hemangiosarcoma (HSA) is a highly aggressive vascular malignancy encountered in veterinary practice and exhibits histopathological and molecular similarities to human angiosarcoma (AS). Despite its clinical importance, the molecular mechanisms driving canine HSA remain poorly understood, limiting the development of effective therapeutic approaches. To address this challenge, we established patient-derived canine HSA 2.5D organoids as a preclinical model. Following validation of lineage-specific marker expression, we evaluated drug responses and performed transcriptomic analyses comparing HSA organoids with nodular hyperplasia (NH) samples to identify molecular alterations associated with malignant transformation. Differential gene expression analysis revealed several genes enriched in HSA, including Phospholipase A and Acyltransferase 3 (
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