Evidence map›Paper›PMID 42797873›Full record

ArticleViruses2026

IRF7 Protects Against Severe Influenza A Infection Independently of TLR7 Recognition in Mice.

Ana Karina Nisperuza Vidal, Chenxiao Wang, Michaela J Allen, Xiaofeng Ding, Jefferson Fernandes Evangelista, Yilin Chen, Mst Shamima Khatun, Micaela R Boxer Wachler, Calder R Ellsworth, Mohammad Islamuddin and 4 more

Abstract read
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ana Karina Nisperuza VidalDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0009-0002-6952-4278
Chenxiao WangDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-7950-9288
Michaela J AllenDepartment of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Xiaofeng DingDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.
Jefferson Fernandes EvangelistaDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Yilin ChenDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.
Mst Shamima KhatunDepartment of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0009-0004-3889-0720
Micaela R Boxer WachlerDepartment of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Calder R EllsworthDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-7111-525X
Mohammad IslamuddinDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0002-4929-8931
Robert BlairDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-9616-9414
Jay K KollsDepartment of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0001-5151-6304
Derek A PociaskDepartment of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Xuebin QinDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, LA 70433, USA.ORCID 0000-0001-9875-983X

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Role of Complement Activation in Severe COVID-19R01HL165265 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QIN, XUEBIN · 2022 to 2025
$2.9M
Renal Macrophage BiologyR01DK129881 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Xuebin Qin · 2022 to 2026
$2.5M
MAC formation and Cell-Specific Inflammasome Activation in COVID-19F31AI191758 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI ELLSWORTH, CALDER R · 2025 to 2025
$50k
American Heart Association-American Stroke Association 962950NHLBI NIH HHS R01 HL165265NIAID NIH HHS F31 AI191758NIDDK NIH HHS R01 DK129881NIH HHS P51 OD011104
6 · The paper itself

Abstract

Influenza A virus (IAV) remains a major cause of respiratory morbidity and mortality worldwide. However, the precise role of the RNA sensor Toll-like receptor 7 (TLR7) and its downstream signaling mediator, interferon regulatory factor 7 (IRF7), during IAV infection remains elusive. To address this gap, we utilized single-cell RNA sequencing (scRNA-seq) alongside

Indexed as

Influenza A virusInterferon Regulatory Factor-7Membrane GlycoproteinsOrthomyxoviridae InfectionsToll-Like Receptor 7AnimalsDendritic CellsDisease Models, AnimalFemaleLungMiceMice, Inbred C57BLMice, KnockoutSignal TransductionInterferon Regulatory Factor-7Irf7 protein, mouseMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7antibody productioninfluenza A virus (IAV)interferon regulatory factor 7 (IRF7)interferon responseToll-like receptor 7 (TLR7)

Identifiers

PMID42797873
PMCPMC13611839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.