In Vitro Assessment of Antiviral Activity of Saikosaponin B2 Against Porcine Epidemic Diarrheal Virus.

Han Zhang, Yue Liu, Fan Zhang, Yibo Xu, Wanli Sha, Shushuai Yi, Baishuang Yin

Abstract read

In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Han ZhangCollege of Animal Science and Technology, Jilin Agricultural Science and Technology College, Jilin 132101, China.

Yue LiuCollege of Animal Science and Technology, Jilin Agricultural Science and Technology College, Jilin 132101, China.

Fan ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.

Yibo XuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.

Wanli ShaCollege of Animal Science and Technology, Jilin Agricultural Science and Technology College, Jilin 132101, China.

Shushuai YiCollege of Animal Science and Technology, Jilin Agricultural Science and Technology College, Jilin 132101, China.ORCID 0009-0003-4463-1154

Baishuang YinCollege of Animal Science and Technology, Jilin Agricultural Science and Technology College, Jilin 132101, China.

Funding

Jilin Province Science and Technology Department 20230202088NC

6 · The paper itself

Abstract

Porcine epidemic diarrhea virus (PEDV) variant strains lead to vaccine failures and significant economic losses in swine farming, highlighting the need for new natural small-molecule antiviral candidates. In this study, we screened a library of 45 small molecules using a cytopathic effect (CPE)-based cytoprotective assay. Saikosaponin B2 (SSB2), a triterpenoid saponin derived from Bupleuri Radix, emerged as the most promising candidate, boasting a selectivity index of 19.77, which surpasses that of most natural compounds. Dose-response tests confirmed SSB2's concentration-dependent anti-PEDV activity, with an inhibitory plateau reached at concentrations above 60 μmol/L (μM). The 50 half-maximal effective concentration (EC

Indexed as

Antiviral AgentsOleanolic AcidPorcine epidemic diarrhea virusSaponinsAnimalsBupleurumCell LineChlorocebus aethiopsCoronavirus InfectionsCytopathogenic Effect, ViralSwineVirus InternalizationVirus ReplicationAntiviral AgentsOleanolic Acidsaikosaponin DSaponinsantiviral activitynatural herbal monomerPEDVsaikosaponin B2variant strain

Identifiers

PMID42797828

DOI10.3390/v18090997

PMCPMC13612102

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.