Ebola Virus RNA Persists in Reproductive Tissues and Sperm of Male

Andrew L Webb, Brayden G Schindell, Kathy Frost, Geoff Soule, Stephanie A Booth, David Safronetz, Jason Kindrachuk

Abstract read

In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrew L WebbDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Brayden G SchindellDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Kathy FrostMycobacteriology, Vector-Borne and Prion Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.

Geoff SouleSpecial Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.

Stephanie A BoothMycobacteriology, Vector-Borne and Prion Diseases Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.

David SafronetzDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0002-9024-728X

Jason KindrachukDepartment of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.ORCID 0000-0002-3305-7084

Funding

Canada Research Chairs 950-231498CIHR PJT-175098

6 · The paper itself

Abstract

Ebola virus (EBOV) has been shown to persist in the reproductive tracts of male Ebola virus disease (EVD) survivors ranging from months to years following recovery, with shedding of EBOV in semen leading to chains of disease transmission. In the current study, we used a mouse model of EBOV infection to investigate the timing of virus infiltration of the male reproductive tissues, the extent of virus persistence in these tissues, and the impact of persistence on tissue health. We challenged male

Indexed as

EbolavirusGenitalia, MaleHemorrhagic Fever, EbolaReceptor, Interferon alpha-betaRNA, ViralSpermatozoaViremiaAnimalsDisease Models, AnimalEpididymisMaleMiceMice, Inbred C57BLMice, KnockoutTestisIfnar1 protein, mouseReceptor, Interferon alpha-betaRNA, ViralEbola virushistopathologyIfnar1−/− micepersistent infectiontesticular infection

Identifiers

PMID42797814

DOI10.3390/v18090983

PMCPMC13612081

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.