Evidence map›Paper›PMID 42797810›Full record

ArticleViruses2026

Powassan Virus Infects Mouse Testes and Reveals a Protective Role for Phagocytic Cells.

E Eldridge Hager-Soto, Esteban Arroyave, Eduardo Eyzaguirre, Omar A Saldarriaga, Alexander N Freiberg, Shannan L Rossi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

E Eldridge Hager-SotoDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Esteban ArroyaveDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Eduardo EyzaguirreDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Omar A SaldarriagaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Alexander N FreibergDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8413-8960
Shannan L RossiDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-2450-2374

Funding

Project 5: mAb Development Flaviviruses and AlphavirusesU19AI181960 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, KUHN, RICHARD J. · 2024 to 2024
$46.7M
EMERGING AND TROPICAL INFECTIOUS DISEASEST32AI007526 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SOONG, LYNN · 1997 to 2025
$3.1M
National Institute of Allergy and Infectious Diseases #T32AI007526-23NIAID NIH HHS T32 AI007526NIAID NIH HHS U19 AI181960NIH HHS 1U19AI196001-25
6 · The paper itself

Abstract

Powassan virus (POWV) is an emerging tick-borne orthoflavivirus with consistently increasing annual prevalence. Though understood as a vector-transmitted virus associated with neurological disease, a 2016 fatal case of an immunocompromised 63-year-old man reported testicular pain with postmortem detection of viral antigen in the testes, suggesting an altered tropism. The extent to which POWV can infect testes remains unclear. We used a BALB/c mouse model of POWV to elucidate the potential of POWV to establish infection in testes and model a potential mechanism of testicular tropism. Here, we report that POWV productively infects the male reproductive tract of mice. We find that POWV consistently infects mouse testes and epididymides at 3 and 5 days post-infection (dpi) with peak titers measuring 6.1 log

Indexed as

PhagocytesTestisAnimalsDisease Models, AnimalMacrophagesMaleMiceMice, Inbred BALB Cdeer tick virusflavivirusmacrophagesmale reproductive tractPowassan virusSertoli celltesticular infection

Identifiers

PMID42797810
PMCPMC13611858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.