Evidence map›Paper›PMID 42797782›Full record

ArticleViruses2026

Identification of a Conserved Linear Epitope in SARS-CoV-2 Nucleocapsid Protein Recognized by Monoclonal Antibody N179.

Zhoujun Su, Junhao Guo, Ning Li, Hefeng Zhou, Jun Ni, Yongjun Cao, Liping Peng, Min Shao, Haitao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhoujun SuSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Junhao GuoSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Ning LiDepartment of Stomatology, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Hefeng ZhouSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Jun NiSchool of Pharmacy, Macau University of Science and Technology, Macau 999078, China.
Yongjun CaoSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Liping PengSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Min ShaoSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.
Haitao LiSchool of Bioengineering, Zhuhai Campus, Zunyi Medical University, Zhuhai 519041, China.

Funding

Guizhou Provincial Key Technology R&D Program QKHZC [2020]4Y219Guizhou Provincial Key Technology R&D Program QKHZC [2023] General 259
6 · The paper itself

Abstract

We previously generated mouse monoclonal antibody N179 against the SARS-CoV-2 nucleocapsid (N) protein and developed a colloidal gold-based immunochromatographic test strip with a 2 ng/mL detection limit and 98% concordance with RT-qPCR. However, the precise epitope recognized by N179 remained undefined. Using GST-fused N protein truncation fragments, Western blotting, and ELISA, we mapped the linear antibody-reactive region to the C-terminal tail of the N protein and identified

Indexed as

Antibodies, MonoclonalAntibodies, ViralCoronavirus Nucleocapsid ProteinsCOVID-19EpitopesSARS-CoV-2Amino Acid SequenceAnimalsConserved SequenceEnzyme-Linked Immunosorbent AssayEpitope MappingHumansMicePhosphoproteinsSequence AlignmentAntibodies, MonoclonalAntibodies, ViralCoronavirus Nucleocapsid ProteinsEpitopesnucleocapsid phosphoprotein, SARS-CoV-2Phosphoproteinscolloidal gold-based immunochromatographic assayepitope mappinglinear B-cell epitopemonoclonal antibodynucleocapsid proteinSARS-CoV-2

Identifiers

PMID42797782
PMCPMC13611893

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.