Evidence map›Paper›PMID 42797756›Full record

ArticleToxics2026

Chemical Distribution Kinetics of Five Polycyclic Aromatic Hydrocarbons in a Microphysiological System.

Katharina S Nitsche, Susana Proença, Wouter Bakker, Paul L Carmichael, Hans Bouwmeester, Nynke I Kramer

Abstract read
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katharina S NitscheDivision of Toxicology, Wageningen University & Research, P.O. Box 8000, 6700 EA Wageningen, The Netherlands.
Susana ProençaesqLABS GmbH, 26683 Saterland, Germany.
Wouter BakkerDivision of Toxicology, Wageningen University & Research, P.O. Box 8000, 6700 EA Wageningen, The Netherlands.ORCID 0000-0002-0345-111X
Paul L CarmichaelDivision of Toxicology, Wageningen University & Research, P.O. Box 8000, 6700 EA Wageningen, The Netherlands.
Hans BouwmeesterDivision of Toxicology, Wageningen University & Research, P.O. Box 8000, 6700 EA Wageningen, The Netherlands.ORCID 0000-0001-9318-4272
Nynke I KramerDivision of Toxicology, Wageningen University & Research, P.O. Box 8000, 6700 EA Wageningen, The Netherlands.

Funding

Unilever SERS
6 · The paper itself

Abstract

As next-generation risk assessment accelerates the shift towards non-animal models, it also necessitates the development of tools that quantify the chemical in vitro distribution to derive an effective concentration. Although several predictive models have already been developed, none have thus far specifically focused on microphysiological systems. Unlike static well plates, microphysiological systems use (micro-) fluidic flow, consist of largely hydrophobic plastic surfaces, and often rely on protein-rich hydrogel matrices for cell scaffolding. However, these properties can alter the nominal concentration in microfluidic systems, thereby affecting the freely available chemical fraction that can reach the cells. Our objective was to measure the mass distribution in the Organoplate 2-lane

Indexed as

mass balance modellingnext-generation risk assessmentorgan-on-chippartitioningtrue dose

Identifiers

PMID42797756
PMCPMC13611211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.