Evidence map›Paper›PMID 42797748›Full record

ArticleToxics2026

Role of Esterase BmeFE4 in Mediating the Alleviating Effects of Resveratrol on NaF-Induced Fluorosis in

Liang Chen, Qilong Zhao, Mengyue Wang, Tongyu Gu, Lei Ding, Xinzhi Wang, Qi Tang, Shangshang Ma, Guorui Liu, Keping Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liang ChenSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0003-4760-5165
Qilong ZhaoSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Mengyue WangSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Tongyu GuSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Lei DingSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Xinzhi WangState Key Laboratory of Natural Medicines, New Drug Screening Center, China Pharmaceutical University, Nanjing 210009, China.
Qi TangSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Shangshang MaSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Guorui LiuSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.
Keping ChenSchool of Biological Science and Technology, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0001-5254-2299

Funding

National Natural Science Foundation of China 31802140Scientific Research Promotion Fund for the Talents of Jiangsu University 14JDG157
6 · The paper itself

Abstract

Fluoride exposure can induce tissue injury and oxidative stress dysregulation, ultimately leading to organismal dysfunction and death, whereas resveratrol (RSV) has been reported to counteract diverse oxidative injuries. Despite its antioxidant potential, the application of RSV is limited by its low bioavailability. Here, using a silkworm model, we established NaF exposure, RSV treatment, and combined RSV+NaF groups to investigate the mechanism by which RSV attenuates fluorosis. Comparative analyses of body weight, histopathological damage, and oxidative stress indices showed that RSV markedly mitigated NaF-induced toxicity. Candidate genes and proteins exhibiting concordant expression changes were identified through integrated RNA-seq and TMT-based quantitative proteomics, and subsequently validated by qPCR and PRM. Among these candidates, the esterase BmeFE4 emerged as a key regulator of the RSV-mediated detoxification response. Spatiotemporal profiling revealed that

Indexed as

association analysisfluorosisproteomeresveratroltranscriptome

Identifiers

PMID42797748
PMCPMC13611032

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.