ArticleToxics2026
Comparative Analysis of Test Methods for Predicting Dermal Sensitization Potency in Essential Oils: A Component-Based Prediction Model, GARDskin Dose-Response Assay, and Local Lymph Node Assay.
Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
The dose-response adaptation of the genomic allergen rapid detection for skin sensitizers (GARDskin DR) assay is a non-animal method for predicting sensitization potency. This proof-of-concept comparative analysis evaluates outputs from a component-based prediction model (CP), GARDskin DR, and historical local lymph node assays (LLNA), exploring the applicability of CP and GARDskin DR for evaluating the no-expected-sensitization induction level (NESIL) potencies of essential oils. Eight well-studied essential oils were selected: cedarwood, cinnamon bark, clove bud, geranium, lavender, lemongrass, spearmint, and tea tree oils. Each underwent GARDskin DR as well as GC-MS, from which CP model outputs were derived. GARDskin DR, CP, and LLNA outputs were compared graphically and using preliminary descriptive statistics. Results show overall statistical concordance in material ranking between methods (Kendall's W = 0.857,
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