Per- and Polyfluoroalkyl Substances (PFAS) in Michigan: A Novel High-Throughput Method with Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Analysis of 39 PFAS Compounds in Human and Bovine Dried Blood Spots (DBS).

Jessica M Morrison, Sarah Y Lockwood-O'Brien, Chelsea A Bielicki, Douglas J Carmack, Julia R Feeley, Timothy A Karrer, Matthew J Geiger

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In one paragraph

Article in Toxics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica M MorrisonBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.ORCID 0000-0001-8186-8036

Sarah Y Lockwood-O'BrienBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Chelsea A BielickiBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Douglas J CarmackBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Julia R FeeleyBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Timothy A KarrerBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Matthew J GeigerBureau of Laboratories, State of Michigan Department of Health and Human Services, 3350 North Martin Luther King Junior Boulevard, Lansing, MI 48906, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents a novel method for analyzing per- and polyfluoroalkyl substances (PFAS) in dried blood spots (DBS), employing a hybrid solvent-based and matrix-matched calibration curve, minimal sample volume, and high-throughput preparation. This process produces a concentrated, purified sample, which is analyzed using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). As part of method validation, key performance metrics such as accuracy, precision, sensitivity, carryover, specificity, interferences, and maximum dilution capability were assessed. The method quantifies 39 PFAS compounds across various classes, achieving limits of detection in the low ng L

Indexed as

analytical sample preparation methodsbiological monitoringdried blood spotsenvironmental monitoringfluorocarbonsliquid chromatography–mass spectrometry

Identifiers

PMID42797672

DOI10.3390/toxics14090753

PMCPMC13611127

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.