Evidence map›Paper›PMID 42797328›Full record

ArticlePharmaceutics2026

Leachable-Derived Impurities in Oral Solid Dosage Forms Generated by Solid-State Packaging-Excipient Interactions: A Case Study of a Polyvinyl Chloride Heat Stabilizer Reacting with Povidone.

Ewoud Vaneeckhaute, Julie Van Hooste, Pasquinel Weckx, Andrew Teasdale, Ruud Cuyvers, Jonathan Hammond, Daniel Wood, Ward D'Autry, Laura Martin, Eric Breynaert

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ewoud VaneeckhauteNMRCoRe, NMR/X-Ray Platform for Convergence Research, KU Leuven, Celestijnenlaan 200F-Box 2461, B-3001 Leuven, Belgium.ORCID 0000-0003-2681-6246
Julie Van HoosteNelson Labs, Romeinsestraat 12, B-3001 Leuven, Belgium.
Pasquinel WeckxNMRCoRe, NMR/X-Ray Platform for Convergence Research, KU Leuven, Celestijnenlaan 200F-Box 2461, B-3001 Leuven, Belgium.ORCID 0000-0001-8796-8265
Andrew TeasdaleNelson Labs, Romeinsestraat 12, B-3001 Leuven, Belgium.
Ruud CuyversNelson Labs, Romeinsestraat 12, B-3001 Leuven, Belgium.
Jonathan HammondNorgine Pharmaceutical Ltd., ARC Uxbridge, Building 01, Sanderson Road, Uxbridge UB8 1DH, UK.
Daniel WoodNorgine Pharmaceutical Ltd., ARC Uxbridge, Building 01, Sanderson Road, Uxbridge UB8 1DH, UK.
Ward D'AutryNelson Labs, Romeinsestraat 12, B-3001 Leuven, Belgium.ORCID 0009-0008-5667-6989
Laura MartinNorgine Pharmaceutical Ltd., ARC Uxbridge, Building 01, Sanderson Road, Uxbridge UB8 1DH, UK.ORCID 0009-0007-4859-437X
Eric BreynaertNMRCoRe, NMR/X-Ray Platform for Convergence Research, KU Leuven, Celestijnenlaan 200F-Box 2461, B-3001 Leuven, Belgium.ORCID 0000-0003-3499-0455

Funding

Flemish Government AH.2016.134, via the hermes fundHerculesstichting AKUL/13/21Research Foundation - FlandersResearch Foundation - Flanders I001321N: Nuclear Magnetic Resonance Spectroscopy Platform for Molecular Water Research
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

blister packagingextractablesICH Q3Eimpurity identificationleachablesoral solid dosage formorganotin heat stabilizerpolyvinyl chloridepovidonepyrrolidin-2-one

Identifiers

PMID42797328
PMCPMC13610799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.