Evidence map›Paper›PMID 42797229›Full record

ArticlePharmaceutics2026

Probing the Capsid: pH-Driven Gating at the AAV 5-Fold Pore and Its Role in Peptide Ligand Binding.

Arianna Minzoni, Benjamin Bobay, Shriarjun Shastry, Eduardo Barbieri, Brandon Brino, Crystal Collazo, Shizuo Kamita, Danni Wang, Ciera Khuu, Alexander Polgar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Arianna MinzoniDepartment of Chemical and Biomolecular Engineering, NC State University, 911 Partners Way, Raleigh, NC 27606, USA.ORCID 0000-0002-4504-9567
Benjamin BobayDuke University NMR Center, Department of Chemistry, Duke University Medical Center, 308 Research Dr, Durham, NC 27710, USA.ORCID 0000-0003-4775-3686
Shriarjun ShastryDepartment of Chemical and Biomolecular Engineering, NC State University, 911 Partners Way, Raleigh, NC 27606, USA.ORCID 0000-0001-9164-9398
Eduardo BarbieriHealth Research Institute, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA.
Brandon BrinoDepartment of Chemical and Biomolecular Engineering, NC State University, 911 Partners Way, Raleigh, NC 27606, USA.ORCID 0009-0004-4158-2729
Crystal CollazoDepartment of Chemical and Biomolecular Engineering, NC State University, 911 Partners Way, Raleigh, NC 27606, USA.ORCID 0009-0004-1213-5647
Shizuo KamitaBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Danni WangBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Ciera KhuuBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Alexander PolgarBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Joseph SiinoBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Sushmita KoleyBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Peyton RusselburgBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Mark SnyderBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Christopher BelisleBio-Rad Laboratories, 1000 Alfred Nobel Drive, Hercules, CA 94547, USA.
Michael DanieleNorth Carolina Viral Vector Initiative in Research and Learning (NC-VVIRAL), NC State University, 911 Oval Dr, Raleigh, NC 27695, USA.ORCID 0000-0002-2016-4091
Stefano MenegattiDepartment of Chemical and Biomolecular Engineering, NC State University, 911 Partners Way, Raleigh, NC 27606, USA.ORCID 0000-0001-5633-434X

Funding

FDA HHS R01 FD007481National Institute for Innovation in Manufacturing Biopharmaceuticals PC8.1-135 and PC9.1-105Triangle Universities Center for Advanced Studies Inc. (TUCASI) NC-VVIRALUnited States Food and Drug Administration R01FD007481U.S. National Science Foundation CBET 2449235
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adeno-associated viruscapsid proteinsdownstream processingmixed-mode chromatographymolecular dynamics

Identifiers

PMID42797229
PMCPMC13610328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.