ArticlePolymers2026
pH- and Near-Infrared Light Dual-Responsive Hydrogel Microneedles Incorporating Polydopamine-Based Curcumin-Loaded Nanoparticles for Antibacterial and Oxidative Injury Protection.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Bacterial infection and persistent oxidative stress can impair wound healing and limit the efficacy of conventional antibacterial therapies. Here, we developed a pH- and near-infrared (NIR) light-responsive polymer hydrogel microneedle (PHMN) system by incorporating curcumin-loaded polydopamine particles (PDA@CUR) into photo-crosslinked methacrylated hyaluronic acid (HAMA) microneedles with a poly(vinyl alcohol) (PVA) backing layer. The synthesized CUR-loaded PDA nanoparticles (PDA@CUR) exhibited uniform spherical morphology, efficient CUR loading, and pH- and NIR light-responsive drug release. The fabricated PHMN/PDA@CUR patch displayed a well-defined array, sufficient mechanical strength, and efficient photothermal conversion under NIR irradiation. The patch could effectively inhibit both
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