ArticleNutrients2026
Gastric Residual Volume as a Candidate Brain-Gut Signal in Neurocritical Care: An Exploratory, Hypothesis-Generating Retrospective Cohort Study.
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
BACKGROUND/
objectivesElevated gastric residual volume (GRV) is traditionally read as feeding intolerance, and randomized trials in general intensive care units (ICUs) have discredited its routine use. Whether this holds in neurocritical patients is unknown.
methodsThis exploratory, hypothesis-generating single-center retrospective cohort study comprised 355 neurosurgical ICU adults with documented GRV (2022-2026)-the exposure was a peak GRV ≥ 250 mL, the institutional feeding-hold threshold (
resultsElevated GRV was not significantly associated with in-hospital mortality (adjusted odds ratio 1.46; 95% confidence interval (CI) 0.52-3.65) and was not associated with greater deterioration in laboratory-based systemic inflammatory/nutritional indices than in comparators, with null mediation. The patient-level maxima of GRV and ICP were correlated before adjustment (ρ = 0.28) and 0.19 after full adjustment (95% CI -0.001 to 0.37,
conclusionsIn neurocritical patients receiving enteral tube feeding with documented GRV monitoring, elevated GRV was not associated with greater deterioration in laboratory-based systemic inflammatory/nutritional indices, whereas a possible association with higher early ICP was observed in a small, monitored subset. Because the ICP-monitored subset was small, these exploratory, hypothesis-generating findings do not establish a brain-gut signal. They raise the hypothesis that elevated GRV in this setting may reflect intracranial rather than solely gastrointestinal processes and require prospective confirmation with temporally paired measurements.
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