Trial reportNutrients2026
Vitamin Insufficiency After Esophagogastric Surgery and Targeted Supplementation: A Multicenter Prospective Intervention Study Named the VITAMIN Study.
Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The trial behind it
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Authors and funding
18 authors.
Funding
Abstract
BACKGROUND/
aimGuidelines on screening for pre or postoperative micronutrients are currently lacking for patients diagnosed with gastric or esophageal cancer. this study aimed to identify micronutrient deficiencies after surgery for esophagogastric neoplasms and to evaluate changes in micronutrient status during targeted supplementation.
methodsThis was a non-randomized prospective intervention trial conducted in The Netherlands between December 2021 and December 2024. Patients who underwent esophagectomy or (sub)total gastrectomy were included. At baseline (T0), blood measurement prior to supplementation was performed. All measurements were repeated after six (T1) and 12 months (T2) of supplementation. Both groups received Calcium Soft Chew D3 and a multivitamin supplement depending on the performed surgery (i.e., Multi-E or Multi-G).
resultsIn total, 107 patients were included (
conclusionDuring targeted supplementation, the prevalence of several micronutrient deficiencies decreased and several micronutrient concentrations increased. Further prospective randomized studies are needed to confirm these findings.
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