ReviewNutrients2026
Dietary Patterns, Micronutrient Adequacy, and Metabolic Vulnerability in Alzheimer's Disease: A Critical Narrative Review.
Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary factors may influence cognitive aging and Alzheimer's disease (AD), but observational associations, mechanistic findings, and intervention effects should not be considered equivalent evidence. This critical narrative review examines how dietary patterns, micronutrient adequacy, and metabolic health may modify AD-related vulnerability. A targeted search of PubMed/MEDLINE, Scopus, and Web of Science through April 2026 prioritized systematic reviews, meta-analyses, randomized trials, and prospective cohorts. Mediterranean, Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), and healthful plant-based dietary patterns have been associated with better cognitive outcomes and lower dementia risk. However, evidence remains predominantly observational, and randomized trials have not consistently demonstrated prevention of cognitive decline. Strict vegan diets have not shown additional protection beyond high-quality plant-based diets and require careful attention to vitamin B12 and overall nutritional adequacy. Ketogenic diets and medium-chain triglycerides may increase cerebral ketone availability, but their cognitive benefits remain inconsistent, and disease modification has not been established. Although vitamin B12, folate, and vitamin D support neural and metabolic functions, correcting deficiency should not be equated with treating AD. Overall, nutrition should be viewed as a contributor to cardiometabolic and neurological resilience and as part of person-centered dementia care, rather than as a stand-alone disease-modifying therapy. Future studies should integrate accurate dietary assessment, objective adherence measures, metabolic phenotyping, AD biomarkers, and clinically meaningful outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.