Evidence map›Paper›PMID 42796987›Full record

ArticleNutrients2026

A Matcha Tea Formulation Containing

Chiara Rucci, Giulia Feliziani, Alice Agarbati, Francesca Comitini, Sauro Vittori, Cinzia Mannozzi, Riccardo Marconi, Laura Bordoni, Rosita Gabbianelli

Abstract read
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara RucciUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0009-0009-4403-2702
Giulia FelizianiUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0009-0003-1247-4422
Alice AgarbatiDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, 60131 Ancona, Italy.
Francesca ComitiniDepartment of Life and Environmental Sciences, Università Politecnica delle Marche, 60131 Ancona, Italy.
Sauro VittoriChemistry Interdisciplinary Project (CHIP), School of Pharmacy, University of Camerino, 62032 Camerino, Italy.
Cinzia MannozziChemistry Interdisciplinary Project (CHIP), School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-8200-909X
Riccardo MarconiChemistry Interdisciplinary Project (CHIP), School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0009-0002-0616-8122
Laura BordoniUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0001-6968-1164
Rosita GabbianelliUnit of Molecular Biology and Nutrigenomics, School of Pharmacy, University of Camerino, 62032 Camerino, Italy.ORCID 0000-0003-0037-7740

Funding

University of Camerino FPD112001 - Gabbianelli Rosita
6 · The paper itself

Abstract

BACKGROUND/

objectivesMatcha tea is widely recognized for its antioxidant and anti-inflammatory properties; however, its health-promoting benefits depend on the gastrointestinal bioaccessibility of its phytochemicals. This study evaluated the impact of combining matcha tea with the probiotic yeast

methodsFormulations of matcha tea alone (M), matcha tea combined with the probiotic yeast (M + P), and the probiotic alone (P) were subjected to in vitro gastrointestinal digestion. Probiotic survival, total antioxidant capacity, and polyphenol profiles were analyzed. The biological effects of the digested fractions were tested on inflamed Caco-2 cell monolayers to assess epithelial barrier integrity and gene expression profiles.

resultsThe digested M + P formulation exhibited a significantly higher polyphenol content compared to M alone, including a 322% increase in gallic acid alongside a 40.5% reduction in caffeine content. Both M and M + P digests protected the intestinal barrier against inflammatory damage, preventing the decline in TEER values. However, only the M + P formulation successfully mitigated the compensatory upregulation of the Claudin-1 gene, while significantly downregulating the pro-inflammatory transcription factor NF-κB and the mitochondrial antioxidant SOD2. Furthermore,

conclusionsEnriching matcha tea with the probiotic yeast

Indexed as

DigestionIntestinal MucosaPhytochemicalsProbioticsSaccharomycetalesTeaAnti-Inflammatory AgentsAntioxidantsCaco-2 CellsHumansIntestinal Barrier FunctionPolyphenolsAnti-Inflammatory AgentsAntioxidantsPhytochemicalsPolyphenolsTeaanti-inflammatory potentialantioxidantfunctional foodLachancea thermotoleransmatchaprobiotic yeast

Identifiers

PMID42796987
PMCPMC13610030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.