Evidence map›Paper›PMID 42796933›Full record

ArticleNutrients2026

Interactions Between Genetic Risk and Macronutrient Intake on Obesity-Related Traits in Sri Lankan Adults.

Manahil M Bineid, Dilki S Perera, Zara Crosbie, Ananda Chandrasekara, Kumari M Rathnayake, Karani Santhanakrishnan Vimaleswaran

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In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Manahil M BineidHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading RG6 6DZ, UK.ORCID 0009-0003-1066-0651
Dilki S PereraDepartment of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura 60170, Sri Lanka.
Zara CrosbieHuman Nutrition, School of Agriculture and Food Science, University College Dublin, D04 V1W8 Dublin, Ireland.
Ananda ChandrasekaraDepartment of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura 60170, Sri Lanka.ORCID 0000-0003-0947-6083
Kumari M RathnayakeDepartment of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura 60170, Sri Lanka.ORCID 0000-0002-6362-1627
Karani Santhanakrishnan VimaleswaranHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading RG6 6DZ, UK.ORCID 0000-0002-8485-8930

Funding

Wayamba University SRHDC/RP/04/19-05
6 · The paper itself

Abstract

BACKGROUND/

objectivesIn Sri Lanka, where obesity is increasingly prevalent, evidence on gene-diet interactions involving macronutrient intake and composition remains limited. We therefore examined these interactions on obesity-related traits.

methodsThis cross-sectional analysis included 398 adults (mean age, 42.5 ± 8.3 years; 60.8% men). Anthropometric measurements defined increased body mass index (BMI) and waist circumference (WC). Dietary macronutrient intake was assessed with a validated tool, and carbohydrate/fat intake patterns were determined based on study population-specific macronutrient cutoffs and interpreted as relative dietary patterns rather than clinically defined diets. A genetic risk score (GRS) was constructed using three single-nucleotide polymorphisms (

resultsThe GRS was positively associated with increased WC (

conclusionsDietary carbohydrate and fat intakes may influence the association between genetic susceptibility and obesity in Sri Lankan adults, particularly under a relatively low-carbohydrate/high-fat pattern.

Indexed as

DietGenetic Predisposition to DiseaseNutrientsObesityAdultAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexCross-Sectional StudiesDietary CarbohydratesDietary FatsFemaleGene-Environment InteractionGenetic Risk ScoreHumansMaleMiddle AgedAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary CarbohydratesDietary FatsFTO protein, humanTCF7L2 protein, humanTranscription Factor 7-Like 2 Proteincarbohydratesfatgene–diet interactiongenetic risk scoreobesitySri Lanka

Identifiers

PMID42796933
PMCPMC13610610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.