Evidence map›Paper›PMID 42796874›Full record

ArticlePlants (Basel, Switzerland)2026

Fusion Partner and ER-Retention Signal Are Associated with Distinct Host Proteomic and Metabolic Responses During Interleukin-15 Production in

Alina Savinova, Pipob Suwanchaikasem, Balamurugan Shanmugaraj, Waranyoo Phoolcharoen

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alina SavinovaCenter of Excellence in Plant-Produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0009-0002-2130-3628
Pipob SuwanchaikasemBaiya Phytopharm Co., Ltd., Bangkok 10330, Thailand.ORCID 0000-0001-7991-6414
Balamurugan ShanmugarajCentre for Natural Products and Functional Foods, Karpagam Academy of Higher Education, Coimbatore 641021, India.
Waranyoo PhoolcharoenCenter of Excellence in Plant-Produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0001-5958-7406

Funding

National Research Council of Thailand N42A670577
6 · The paper itself

Abstract

Plant molecular farming has emerged as a promising platform to produce recombinant biopharmaceuticals. The expression of foreign proteins changes the host proteome and metabolome, and these changes might have an effect on the accumulation of recombinant proteins. In this study, we investigated how fusion partners and ER-retention strategies influence host responses during transient production of recombinant human interleukin-15 (IL-15) in

Indexed as

endoplasmic reticulum retentioninterleukin-15metabolomicsplant molecular farmingproteomicsrecombinant biopharmaceuticalsrecombinant protein production

Identifiers

PMID42796874
PMCPMC13610313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.